The problems begin if you need to place a 14 or even 16 layers into a 1.6mm multilayer PCB with impedance controlled high-speed signals. The problem is that we need to use a very thin prepregs and not every manufacturer has them or can use them. When you need to make this type of multilayer PCB you always need to discuss your stuck up with your manufacturer, multilayer PCB because you can make a design that can’t be produced or will be way too expansive for your customer. In the conclusion I want to give you a couple of advice that may help you in your work:
Before start calculating stuck up look at the powers of your manufacturer, what materials he has.